Hummingbird SEM Liquid Stage in Microscope

SEM Liquid

Technical Specs

Hummingbird Scientific SEM Stage - ElectroChemistry Liquid Flow Cell - Cross Correllative TEM Holder
1400 Series SEM
Number of Inlets 1 or 2 depending on model, single outlet
Biasing Contacts 3 or 4 depending on model
Tubing Type Replaceable microfluidic tubing
Delivery System Variable-speed liquid delivery system
Tip Type Removable tip
Flow Type Continuous or static liquid flow
SEM Compatibility Custom integration

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Features

Featured Research

Cross-Correlative Studies

Researchers studying the interaction of biological structures with the environment have long been hindered by the lack of a single microscopy technique capable of spanning all relevant length scales. In response to this problem, we are working to develop systems that combine two or more imaging techniques. The SEM liquid holder, for example, enables researchers to perform cross-correlative experiments and to image specimens in the ambient environment. Using the system, researchers at Evergreen State College, Ames Laboratory, and the University of Georgia have successfully taken correlative images of biological specimens using LM, SEM, and TEM.

Figure: Correlating fluorescence (top) and SEM images of autofluorescent Anthrospira in phosphate-buffered saline (bottom), both taken using Hummingbird’s correlative system.

Reference: D.A. Fischer, D.H. Alsem, B. Simon, T. Prozorov and N. Salmon. “Development of an Integrated Platform for Cross-Correlative Imaging of Biological Specimens in Liquid using Light and Electron Microscopies.” Microscopy and Microanalysis 19:Suppl. 2 (2013) pp. 476–477. Abstract

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Selected Publications

D.A. Fischer, D.H. Alsem, B. Simon, T. Prozorov, and N. Salmon. “Development of an Integrated Platform for Cross-Correlative Imaging of Biological Specimens in Liquid using Light and Electron Microscopies.” Microscopy and Microanalysis 19:Suppl. 2 (2013), pp. 476–477 Abstract

 

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